Get hold of nearby state professional licensing board or state-managed substances authority for information on how to circumvent and detect abuse or diversion of this solution.
If an opioid analgesic is initiated inside a client currently using a benzodiazepine or other CNS depressant, prescribe a lessen initial dose in the opioid analgesic, and titrate based on clinical response. Tell sufferers and caregivers of the potential interaction, teach them to the signs and signs of respiratory despair (such as sedation).
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If concomitant use is warranted, Examine clients for signs of diminished diuresis and/or consequences on blood pressure level and increase the dosage with the diuretic as necessary.
Talk with your Health care service provider about naloxone, a medicine for that emergency remedy of an opioid overdose.
Embryo-Fetal Toxicity Tell female patients of reproductive opportunity that acetaminophen and codeine phosphate tablets could potentially cause fetal hurt and to tell the prescriber of a recognized or suspected pregnancy (see Safety measures, Pregnancy).
When you've got been using acetaminophen and codeine phosphate tablets routinely, don't quit getting acetaminophen and codeine phosphate tablets devoid of conversing with your Health care company.
Fatal Unwanted side effects can happen if you use codeine with alcohol, or with other medicines that result in drowsiness, sedation or slow your breathing.
Adults should not choose greater than 4000 milligrams (4 grams) of acetaminophen each day. People with liver complications and youngsters should really just take significantly less acetaminophen. Request your physician or pharmacist how much acetaminophen is Harmless to acquire.
Advise sufferers and caregivers that likely fatal additive results may perhaps occur if click here acetaminophen and codeine phosphate tablets are utilised with benzodiazepines or other CNS depressants, including alcohol, rather than to employ these medicines concomitantly Except supervised by a healthcare supplier (see WARNINGS and Safeguards, Drug Interactions).
If a CYP3A4 inducer is discontinued, think about acetaminophen and codeine phosphate tablets dosage reduction and evaluate clients at Regular intervals for signs of respiratory despair and sedation.
Respiratory despair can take place Anytime during opioid therapy, particularly when initiating click here and next dosage will increase with acetaminophen and codeine phosphate tablets. Take into consideration this threat when here picking out an initial dose and when generating dose get more info changes (see WARNINGS).
Misuse and abuse of acetaminophen and codeine phosphate tablets boosts risk of overdose, which may bring on central nervous process and respiratory depression, hypotension, seizures, click here and Demise. The chance is elevated with concurrent abuse of acetaminophen and codeine phosphate tablets with Liquor and also other CNS depressants.
Other soreness relievers (for instance naproxen, ibuprofen) may be prescribed using this type of medication. Question your health care provider or pharmacist about applying this solution securely with other medicines.